写的:
疫苗临床开发副总裁 & 免疫疗法，澳门在线赌城娱乐
Head of Virology and Vaccine Discovery, Early Vaccines and 免疫疗法，澳门在线赌城娱乐
The ever-evolving infectious disease landscape requires researchers to move quickly to adapt and develop solutions to prevent people from experiencing severe outcomes of disease. 在澳门在线赌城娱乐, we are exploring innovative technologies to maximise the potential of vaccines – with the goal of protecting as many people as possible from the burden of noncommunicable diseases.
免疫系统:澳门第一赌城在线娱乐抵御入侵者的第一道防线
Our immune system’s job is to keep us healthy and protect us from diseases such as those caused by outside invaders like viruses and bacteria. When an invading pathogen such as a virus enters the body of someone with a healthy immune system, 这个人的免疫系统会识别, 攻击并摧毁病毒. The immune system’s response against such a pathogen can be “remembered” by the immune system so that the next time the same person is exposed to the same virus, 免疫反应更强, 更快更有效.1
Vaccines help to keep us healthy because they “prime” the immune system by teaching our bodies how to respond to a pathogen before it can cause disease. When a person who has received a vaccine for a specific pathogen is then exposed to said pathogen, the immune system will quickly mount an attack to prevent the infection from taking hold and spreading. 实际上，疫苗模仿自然感染而不引起疾病.2 疫苗每年挽救数百万人的生命.
目前的疫苗依赖于弱疫苗, inactivated or purified parts of a pathogens to stimulate an immune response.2 然而, there is an opportunity to create vaccines that can help protect us against more diseases by generating a durable immune response or an improved immune response in populations that have weaker immune systems like older adults and those with other comorbidities such as chronic respiratory or cardiovascular diseases.
什么是类病毒颗粒?
类似病毒的粒子, 或车牌区域, is a type of vaccine that mimics how naturally occurring viruses appear to our bodies. VLPs assemble to mimic the structure of a real virus but are not infectious and therefore do not cause disease. VLPs are made up of a central component that acts as a scaffold and numerous antigen-specific components. 结合时, these components self-assemble to form the familiar shape of a natural virus as they appear to our immune system. This may prompt a stronger, more durable and possibly broader immune response from the body.
了解更多关于澳门第一赌城在线娱乐如何利用VLPs推进疫苗开发的信息
While current VLP vaccines effectively protect against several different diseases, 包括乙型肝炎, 人乳头瘤病毒感染与疟疾, the use of the VLP approach in other vaccines has been limited due to challenges with stability, 制造困难, 生产成本高，对温度敏感.3
下一代VLP疫苗技术
We are exploring the use of breakthrough computational methods to solve how to construct and manufacture VLPs resembling complex viruses. Our cutting-edge approach to VLPs may allow us to predict how viral proteins behave and fold into specific shapes. These individual viral proteins can be expressed and purified using new mRNA technology or traditional recombinant technologies and, 当混合, 自发地自组装成VLP, 它们的大小和形状可以和真正的病毒一样. 此外, 而vlp的中心支架组件保持不变, the antigen-specific components can be tailored to resemble various viruses.
VLPs can have one antigen target per VLP (protecting against one specific virus), or they can have multiple different antigens on a single VLP (protecting against different viruses in combination).
扩大VLPs的效益
通过如此逼真地模仿病毒, our VLPs vaccines have the potential to improve upon existing vaccine technology. 通过有意设计的vlp, our aim is to produce better vaccines that may result in a stronger and more durable immune response to reduce the frequency of booster shots and offer a greater degree of protection against related viral strains.
在澳门在线赌城娱乐, we are leveraging our decades of experience in vaccine and antibody development to maximise the potential of cutting-edge VLP vaccines. Our goal is to develop next-generation vaccines that provide long-lasting immunity to as many people as possible, 保护他们免受传染病的严重负担.
